His major area of study and research is in the field of brain imaging. Dr Sinclair has published papers on a range of topics including supernova cosmology, space plasma physics, heritability of brain networks and effects of physical exercise interventions on brain atrophy in elderly people.
A number of users demonstrate immediate and marked improvements in walking and posture, which persists through regular use. Regular use also produces visually evident increases in muscle tone, and some users report improvements in memory and reduction in pain symptoms from pre-existing ailments.
The REVIVER machine fully supports the participant whilst moving them through a range of body positions. These body positions engage strongly and simultaneously a set of core and peripheral muscles required to keep the body upright. This engagement will strengthen those muscles and strengthen the neural pathways from the brain to those muscles, which may have weakened through non-use.
The REVIVER activates this response by placing the participant on positions at the edge of, and beyond their balance. This strong survival response appears to be recruiting motor patterns and muscles which had become weak through lack of use and reduced signaling, and which are no longer activated through the participants other physical activities or daily living.
One of the major design principles of the REVIVER is to maximise the effects of gravity, and to maximise the participants' counter-reaction to gravity.
Counteracting these torques requires substantial muscular activation, yet due to the support of the machine, this muscular activation is possible for most participants, even those with substantial movement impairment.
The drastic improvements observed after relatively short periods of use on the REVIVER exercise machine are most likely due to a process of neuromodulation.
Neuromodulation has been used effectively for Parkinson’s Disease patients, whereby an implantable pulse generator is implanted in areas identified via Magnetic Resonance Imaging as defective.
The REVIVER uses a very similar principle to CN-NINM, but is even less invasive. The stimulus is the periodic perturbation of the vestibular system via circular motion at a tilted angle.
Since the Reviver allows people to perform movement they may otherwise be unable to perform, then a large part of the benefit of the Reviver derives from allowing people to tap in to these benefits of exercise which were previously unavailable to them.
In summary, early observations indicate that the REVIVER is extremely promising as an exercise machine and even as a therapeutic tool.
At this point we can say with very little speculation that the Reviver machine is particularly adept as a tool for elderly users with reduced function, as the machine assists them to perform motions beyond their current physical capabilities, and activates muscles which are rarely used in day to day activities and are thus subject to atrophy.
The REVIVER inputs a strong, targeted and novel stimulus simultaneously to the user being engaged in some task, which is a hallmark of a number of more high tech neuromodulation strategies. This combination is thought to optimally stimulate neuroplasticity and strengthen the users' natural neural systems, which could explain the rapid improvements in walking and posture in some users.
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